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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
13.94
Human Site:
S1119
Identified Species:
19.17
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.19
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
S1119
K
I
T
Y
E
R
D
S
F
R
Q
A
Y
E
D
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
N1119
K
I
T
Y
E
R
D
N
F
R
Q
A
Y
E
D
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
S1118
K
I
T
Y
E
R
D
S
F
R
Q
A
Y
E
D
Dog
Lupus familis
XP_535848
1288
147094
H1119
K
I
T
C
E
R
D
H
F
R
Q
A
Y
E
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
N1117
K
I
T
S
E
R
D
N
F
R
Q
A
Y
E
D
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
K1054
A
A
R
K
R
A
K
K
A
K
Q
A
F
E
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
K902
Q
A
Y
E
D
L
R
K
Q
R
L
N
E
F
M
Chicken
Gallus gallus
NP_989849
1274
145838
R1090
D
I
T
N
E
R
D
R
F
R
Q
A
F
E
D
Frog
Xenopus laevis
P50532
1290
146971
S1113
E
I
T
N
E
R
D
S
F
R
R
A
Y
E
D
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
S1118
D
I
T
T
Q
R
D
S
F
K
R
G
C
E
D
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
K1114
Q
I
T
T
E
R
D
K
F
K
C
A
Y
E
D
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
T1472
E
K
G
N
E
F
D
T
Q
L
A
E
Y
Q
K
Honey Bee
Apis mellifera
XP_396862
1282
148175
R1032
K
I
T
I
E
R
N
R
I
R
D
I
Y
E
T
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
K1206
I
A
T
E
V
H
R
K
H
N
Q
E
L
Q
R
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
E1116
A
L
T
E
K
R
N
E
Q
R
R
Q
L
E
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
D1070
S
V
T
Q
E
R
D
D
T
R
K
Q
Y
D
E
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
E1217
E
L
S
Y
Y
V
E
E
T
N
V
D
I
G
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
93.3
100
86.6
N.A.
86.6
20
N.A.
6.6
73.3
80
53.3
66.6
20
53.3
13.3
33.3
P-Site Similarity:
100
100
100
86.6
N.A.
93.3
33.3
N.A.
20
80
93.3
73.3
80
40
60
20
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
18
0
0
0
6
0
0
6
0
6
53
0
0
0
% A
% Cys:
0
0
0
6
0
0
0
0
0
0
6
0
6
0
0
% C
% Asp:
12
0
0
0
6
0
65
6
0
0
6
6
0
6
59
% D
% Glu:
18
0
0
18
65
0
6
12
0
0
0
12
6
71
6
% E
% Phe:
0
0
0
0
0
6
0
0
53
0
0
0
12
6
0
% F
% Gly:
0
0
6
0
0
0
0
0
0
0
0
6
0
6
0
% G
% His:
0
0
0
0
0
6
0
6
6
0
0
0
0
0
0
% H
% Ile:
6
59
0
6
0
0
0
0
6
0
0
6
6
0
0
% I
% Lys:
36
6
0
6
6
0
6
24
0
18
6
0
0
0
6
% K
% Leu:
0
12
0
0
0
6
0
0
0
6
6
0
12
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
6
% M
% Asn:
0
0
0
18
0
0
12
12
0
12
0
6
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
12
0
0
6
6
0
0
0
18
0
48
12
0
12
6
% Q
% Arg:
0
0
6
0
6
71
12
12
0
65
18
0
0
0
6
% R
% Ser:
6
0
6
6
0
0
0
24
0
0
0
0
0
0
0
% S
% Thr:
0
0
77
12
0
0
0
6
12
0
0
0
0
0
6
% T
% Val:
0
6
0
0
6
6
0
0
0
0
6
0
0
0
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
6
24
6
0
0
0
0
0
0
0
59
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _